Binghamton University

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Targeted Legumain-Cleavable Top1i ADC Platform

This technology introduces a legumain-cleavable antibody drug complex that delivers a topoisomerase inhibitor directly into tumor cells. Its short, polar linker design enables controlled intracellular release, improving targeting precision and therapeutic potential. In contrast to other related technologies, this invention employs low-potency Top1i...

A New Bioorthogonal Reaction

This technology enables extremely fast and stable bioconjugation using a unique boron–nitrogen bond-forming reaction. It works efficiently in water at neutral pH, avoiding harsh conditions required by many existing methods. The approach delivers rapid, clean, and reliable coupling for sensitive biological systems, supporting fast labeling workflows...