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Next-Generation Potent and Selective ASCT2 Transport Inhibitors
This technology introduces highly potent and selective small-molecule inhibitors that block glutamine transport through the ASCT2 transporter, a critical metabolic gateway for many aggressive cancers. These compounds overcome the low affinity and poor specificity of existing inhibitors, enabling more effective therapeutic development and precise research...
Published: 4/28/2026
|
Updated: 8/23/2021
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Inventor(s):
Christof Grewer
,
Elias Ndaru
,
Yueyue Shi
,
Laura Zielewicz
Keywords(s):
#SUNYresearch
,
Technologies
Category(s):
Campus > Binghamton University
,
Technology Classifications > Biological Materials
Enzyme-Based Technology for Targeted Biofilm Disruption and Infection Control
This invention presents a novel enzymatic strategy to dismantle bacterial biofilms by depleting pyruvate, a key metabolite essential for biofilm stability and persistence. By disrupting this metabolic foundation, the technology enhances antibiotic efficacy, reduces infection recurrence, and offers a targeted, resistance-minimizing approach for medical,...
Published: 4/28/2026
|
Updated: 1/17/2020
|
Inventor(s):
Karin Sauer
,
Amber Doiron
,
James Goodwine
Keywords(s):
#SUNYresearch
,
Technologies
Category(s):
Campus > Binghamton University
,
Technology Classifications > Biological Materials
Novel compound to enhance the activity of antimicrobial agents against bacterial biofilms for oral and veterinary health
This invention introduces a biofilm dispersion technology that uses a naturally occurring signaling molecule to induce bacteria to transition from biofilm to planktonic states, making them more susceptible to antimicrobial agents. Effective at nanomolar concentrations, this compound enhances antibiotic efficacy while reducing resistance risks, supporting...
Published: 2/13/2026
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Updated: 9/2/2015
|
Inventor(s):
David Davies
Keywords(s):
#SUNYresearch
,
Technologies
Category(s):
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Biological Materials
,
Campus > Binghamton University