Next-Generation Potent and Selective ASCT2 Transport Inhibitors
This technology introduces highly potent and selective small-molecule inhibitors that block glutamine transport through the ASCT2 transporter, a critical metabolic gateway for many aggressive cancers. These compounds overcome the low affinity and poor specificity of existing inhibitors, enabling more effective therapeutic development and precise research...
Enzyme-Based Technology for Targeted Biofilm Disruption and Infection Control
This invention presents a novel enzymatic strategy to dismantle bacterial biofilms by depleting pyruvate, a key metabolite essential for biofilm stability and persistence. By disrupting this metabolic foundation, the technology enhances antibiotic efficacy, reduces infection recurrence, and offers a targeted, resistance-minimizing approach for medical,...