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This ultraflexible liposome gel delivers lidocaine through the skin to provide deeper and longer-lasting local anesthesia without injections. By combining highly deformable vesicles with a stable gel matrix, the system enhances transdermal penetration, supports sustained release, and improves patient comfort. It offers a needle-free approach that outperforms...

This invention repurposes vilazodone, a serotonin reuptake inhibitor and 5-HT1A partial agonist, for dual-action therapy with L-DOPA to reduce Parkinson’s dyskinesia without diminishing motor benefits, offering a more effective long-term treatment strategy. Background: L-DOPA is the gold-standard treatment for Parkinson’s disease, but...