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Method and Composition for Biocatalytic Protein-Oligonucleotide Conjugation

Efficient and selective method to catalytically ligate a polypeptide to a nucleic acid in a single step Background: Site-specific selective protein modification procedures have been useful for oriented protein immobilization, studies of naturally occurring post-translational modifications, creating antibody-drug conjugates, introduction of fluorophores...

Published: 9/8/2024 | Inventor(s): Brian Callahan, Timothy Owen

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Campus > Binghamton University

Synthesis and Potential Uses of 2-(N-(2-(Fmoc)ethyl)-2-(6-(tert-butoxycarbonylamino)pyridin-3-yl)acetamido) Acetic Acid

Synthesis of peptide nucleic acids with modified nucleobases with high affinity to recognize and complex double-stranded RNA at physiologically relevant conditions Background: Compared to DNA, molecular recognition of double stranded RNA has received relatively little attention. Since it has been discovered that RNA can catalyze chemical reactions,...

Published: 11/16/2023 | Inventor(s): Eriks Rozners, Thomas Zengeya

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Research Tools and Reagents, Campus > Binghamton University

A New Bioorthogonal Reaction

A fast, stable, versatile biomolecule coupling technology based on a bioorthogonal reaction that can occur at neutral pH and room temperature Background: “Click Chemistry” reactions are high yielding, wide in scope, create only byproducts that can be removed without chromatography, simple to perform, and can be conducted in easily removable...

Published: 7/13/2022 | Inventor(s): Susan Bane Tuttle, Özlem Dilek, Kamalika Mukherjee

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Antibodies, Campus > Binghamton University