Traceless Protein–DNA Conjugation for Next-Gen Biotech
This invention introduces a fast, site-specific enzymatic method for attaching oligonucleotides to proteins with near-traceless precision, enabling cleaner, more functional conjugates for diagnostics, therapeutics, and nanotechnology.
Background:
Conventional methods for protein–oligonucleotide conjugation often suffer from slow reaction rates,...
Stable RNA targeting using triple helix forming peptide nucleic acids
This invention introduces modified peptide nucleic acids that can recognize double-stranded RNA with high strength and sequence selectivity under physiological conditions. By enabling stable triple helix formation at neutral pH, these molecules overcome limitations of traditional approaches that require acidic environments. The technology opens new...
A New Bioorthogonal Reaction
This technology enables extremely fast and stable bioconjugation using a unique boron–nitrogen bond-forming reaction. It works efficiently in water at neutral pH, avoiding harsh conditions required by many existing methods. The approach delivers rapid, clean, and reliable coupling for sensitive biological systems, supporting fast labeling workflows...