Cardiac output is one of the most important indicators of cardiovascular health, yet it remains difficult to measure outside of clinical settings. Traditional methods often require invasive catheterization procedures that are expensive, time-consuming, and associated with patient risk, while existing non-invasive systems are typically not portable, wired, and limited to short-duration monitoring. As remote patient monitoring and wearable health technologies continue to grow, there is a significant need for a portable solution that is capable of continuously monitoring cardiac output during normal daily activities with clinically relevant accuracy.
The invention utilizes a high-sensitivity MEMS accelerometer positioned on the sternum to measure infrasonic chest wall movements generated by cardiac contractions. Proprietary signal processing algorithms combine continuous wavelet transforms, contraction time location detection, and genetic algorithm-optimized wavelet filter selection to isolate ventricular contraction events and estimate stroke volume directly from chest acceleration signals. The system incorporates a 24-bit analog-to-digital conversion architecture that minimizes signal saturation and improves performance during breathing, movement, and exercise.
• Demonstrates approximately 89–90% correlation with the FDA-approved NICOM bio-impedance cardiac output monitoring system during human subject testing
• Incorporates a 24-bit analog-to-digital converter, improving signal quality and reducing saturation issues associated with lower-resolution systems in noisy or motion-rich environments
• Designed for implementation as a portable, battery-operated device capable of long-term ambulatory cardiac monitoring
• Eliminates the need for a separate ECG measurement by extracting ventricular contraction timing directly from chest wall acceleration signals
• United States Patent 16/751,933 (Divisional) – Filed 1/24/2020, Issued 10/25/2022
• United States Patent 15/182,087 (Continuation) – Filed 6/14/2016, Issued 1/28/2020
• Published patent information available
Bench-top prototype - with proof-of-concept validation
This technology is available for licensing.
Strong potential for remote patient monitoring providers, wearable health technology developers, digital health companies, sports performance platforms, and clinical monitoring system manufacturers seeking portable, non-invasive cardiac output monitoring solutions.
Prototype performance data and additional validation information available upon request.