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This technology enables precise activation of the immune system by delivering potent TLR7/8 agonists directly to diseased cells. By combining immune stimulators with antibody targeting, it enhances therapeutic impact while minimizing systemic side effects. The approach offers a safer and more effective way to treat cancer and infectious diseases by...

This ultraflexible liposome gel delivers lidocaine through the skin to provide deeper and longer-lasting local anesthesia without injections. By combining highly deformable vesicles with a stable gel matrix, the system enhances transdermal penetration, supports sustained release, and improves patient comfort. It offers a needle-free approach that outperforms...

Measuring oxidative stress in living systems is a critical challenge—current detection methods rely on unstable ROS markers or harsh chemical assays that damage cells and prevent real-time analysis. This invention introduces biocompatible fluorescent probes that directly detect oxidative stress–induced carbonylation in live cells and tissues,...

This technology introduces a genome-edited whole-cell cancer vaccine engineered to remove key immune evasion signals such as CD47, enabling robust macrophage activation and enhanced antigen presentation. The edited, non-replicating tumor cells stimulate durable, systemic anti-tumor immunity with fewer off-target effects than antibody-based checkpoint...

This invention repurposes vilazodone, a serotonin reuptake inhibitor and 5-HT1A partial agonist, for dual-action therapy with L-DOPA to reduce Parkinson’s dyskinesia without diminishing motor benefits, offering a more effective long-term treatment strategy. Background: L-DOPA is the gold-standard treatment for Parkinson’s disease, but...

This invention uses a detergent-free decellularized pancreatic extracellular matrix (dpECM) to direct human pluripotent stem cells into self-assembled, vascularized pancreatic islet organoids. By recreating the native pancreatic microenvironment, the technology promotes β-cell maturation, multicellular organization, and glucose-responsive insulin...

This invention introduces a fast, site-specific enzymatic method for attaching oligonucleotides to proteins with near-traceless precision, enabling cleaner, more functional conjugates for diagnostics, therapeutics, and nanotechnology. Background: Conventional methods for protein–oligonucleotide conjugation often suffer from slow reaction rates,...